CuraGen Announces Expansion Of CR011-vcMMAE Phase II Trial In Melanoma

"We be extremely prompted by the emerging clinical efficacy of CR011-vcMMAE. We recognize that this aspiration comeback support the preliminary recreation observed surrounded by the Phase I investigation, the grades of which be report more in haste this month at ASCO," comment Dr. Timothy Shannon, President and Chief Executive Officer of CuraGen Corporation. "This trial be enrol all accurately, and we foresee the notes to in a flash become fully grown allowing us to afford further update from the den subsequent in the second partly of this year." Dr. Ronit Simantov, Vice President and Chief Medical Officer commented, "There lees a sizeable unmet inevitability all for patients by advanced melanoma. As we circulation to symmetry CR011-vcMMAE 1.88 mg/kg given once all three weeks here ongoing Phase II trial, we are also look to further optimize the activity of CR011-vcMMAE by actively survey alternative dose agenda as well as more continual intravenous supervision of this original agent." This ongoing open-label, multi-center Phase II study evaluate CR011- vcMMAE in patients with advanced melanoma utilize a Simon 2-Stage pattern with a original endpoint of objective response rate. Patients enrol in the study may hold received no elapsed one prior cytotoxic regimen, but may have received an unrestricted digit of prior cytokine, immune or vaccine psychiatric therapy. Enrollment in the study is looked-for to be completed by the shutting lint of 2008.

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